Evidence from recent EU research projects has demonstrated that the current EU law systematically underestimates the risk from combined exposures. It is high time to move ahead and improve the protection of human health and the environment from mixture effects due to combined exposures. We support the introduction of a MAF of 100 in the derivation of the DNEL/PNEC under REACH. However, as much as a MAF is indispensable, it is not sufficient to adjust chemical regulations to the reality of chemical exposure. Read this paper to find out more about our views.